Gynecologic Diseases

Fluorescence diagnosis and photodynamic therapy in intra-abdominal gynecologic diseases and breast cancer – A review

Author(s): Martin Löning, Philipp Soergela and Peter Hillemanns

Fluorescence diagnosis (FD) and photodynamic therapy (PDT) with 5-aminolevulinic acid (5-ALA)-induced protoporpyrin IX are promising new options in the diagnosis and therapy of diseases in a wide spectrum of medical disciplines such as urology, dermatology, gastroenterology and neurosurgery. FD is based on the application of the heme precursor 5-ALA which induces the endogenous accumulation of the photosensitizer protoporphyrin IX (PpIX) in designated tissues. After excitation with blue light, a strong red fluorescence can be initiated particularly in tumorous tissues. PDT involves the use of photochemical reactions mediated through the interaction of photosensitizing agents, light and oxygen for the treatment of malignant or benign diseases.